Article

Molecular determinants of cardiac lymphatic dysfunction in a chronic pressure-overload model

2025-02-27

Abstract excerpt

Cardiac lymphatics have emerged as potential targets in cardiovascular diseases (CVDs). However, we recently reported that despite extensive lymphatic expansion during experimental cardiac pressure-overload, lymphatic drainage remained insufficient. To unravel the cellular and molecular mechanisms underlying lymphatic dysfunction in CVDs, we applied cardiac single-cell (sc) analyses in a murine heart failure model...

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Literature Corpus work: 677b0517-f9b3-5b94-a00c-f9e27695545a
DOI: 10.1101/2025.02.27.640360

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