Article

Meta-analysis of tumor and T cell intrinsic mechanisms of sensitization to checkpoint inhibition

2020-09-16

Abstract excerpt

Checkpoint inhibitors (CPIs) augment adaptive immunity. Systematic pan-tumor analyses may reveal the relative importance of tumour cell intrinsic and microenvironmental features underpinning CPI sensitization. Here we collated whole-exome and transcriptomic data for >1000 CPI-treated patients across eight tumor-types, utilizing standardized bioinformatics-workflows and clinical outcome-criteria to validate multiva...

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Literature Corpus work: 82bd7799-15aa-5467-a4c5-8c49cf99cb30
DOI: 10.21203/rs.3.rs-76468/v1

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