Article

A comparative study of endoderm differentiation in humans and chimpanzees

2017-05-09

Abstract excerpt

There is substantial interest in the evolutionary forces that shaped the regulatory framework that is established in early human development. Progress in this area has been slow because it is difficult to obtain relevant biological samples. Inducible pluripotent stem cells (iPSCs) provide the ability to establish in vitro models of early human and non-human primate developmental stages. Using matched iPSC panels f...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 82b7e030-d308-57e1-abf1-7e1c9294e08f
DOI: 10.1101/135442

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A comparative study of endoderm differentiation in humans and chimpanzeesDOI 10.1101/135442Read

Embryoid bodies facilitate comparative analysis of gene expression in humans and chimpanzees across dozens of cell typesSemantic proximity Read

Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expressionSemantic proximity Read

Evolutionary insights into primate skeletal gene regulation using a comparative cell culture modelSemantic proximity Read

Developmental signaling reveals functionally enriched human-specific gene regulation in telencephalic progenitorsSemantic proximity Read

Transcriptomic Analysis Identifies Transient Mesendodermal State and Lineage Divergence in Human Pluripotent Stem Cell DifferentiationSemantic proximity Read

Functional genomics analysis of developing zebrafish and human endoderm reveals highly conserved cis-regulatory modules controlling vertebrate organogenesisSemantic proximity Read

Genetic studies of human-chimpanzee divergence using stem cell fusions.Semantic proximity Read

Multi-omics analysis reveals a crucial role for Retinoic Acid in promoting epigenetic and transcriptional competence of an <i>in vitro</i> model of human Pharyngeal EndodermSemantic proximity Read

A single-cell transcriptome atlas of human early embryogenesisSemantic proximity Read

Single-cell analysis of preimplantation embryonic development in guinea pigsSemantic proximity Read

An integrated transcriptomic cell atlas of human endoderm-derived organoidsSemantic proximity Read

Single-cell time-series mapping of cell fate trajectories reveals an expanded developmental potential for human PSC-derived distal lung progenitorsSemantic proximity Read