Article

Protective effect of CACNA1A deficiency against seizure in the CACNA1A-CELSR2 digenic knockdown flies

2023-02-01

Abstract excerpt

<title>Abstract</title> <p>The vast majority of medically intractable epilepsy cases can be traced to polygenic backgrounds, and pathogenic variants contribute to genetic risk in the complex inheritance of this common disorder. We generated monogenic and digenic <italic>drosophila</italic> models by knock-down of two epilepsy-associated genes, CACNA1A and CELSR2, with impacts on intersynaptic calcium activities....

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Literature Corpus work: 82907f16-963f-5252-b348-8c8b2634092e
DOI: 10.21203/rs.3.rs-2533657/v1

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