Article

Decoding non-human mammalian adaptive signatures of 2.3.4.4b H5N1 to assess its human adaptive potential

2024-08-26

Abstract excerpt

<h4>ABSTRACT</h4> The recent panzootic 2.3.4.4b clade H5N1 infected diverse non-human mammalian species globally, showed mammal-to-mammal transmission among them and caused sporadic human infections. However, whether 2.3.4.4b H5N1 circulating in non-human mammals can establish human infections and spread among humans is unclear. Gain-of-function research restrictions preclude assessing human adapting mutations of...

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Literature Corpus work: 18ca1b16-5a8b-5980-acd4-81ccb5974d1f
DOI: 10.1101/2024.08.26.609722

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