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Article

Cancer drug resistance: an evolving paradigm.

Nature reviews. Cancer - 1 Oct 2013

Holohan Caitriona, Van Schaeybroeck Sandra, Longley Daniel B, Johnston Patrick G

Abstract excerpt

Resistance to chemotherapy and molecularly targeted therapies is a major problem facing current cancer research. The mechanisms of resistance to 'classical' cytotoxic chemotherapeutics and to therapies that are designed to be selective for specific molecular targets share many features, such as alterations in the drug target, activation of prosurvival pathways and ineffective induction of cell death. With the...

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PMID: 24060863
DOI: 10.1038/nrc3599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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