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Article

Investigating the Impact of Dimer Interface Mutations on Norrin's Secretion and Norrin/β-Catenin Pathway Activation.

Investigative ophthalmology & visual science - 5 Mar 2024

Liu Min, Dai Erkuan, Yang Mu, Li Shujin, Fan Lin, Liu Yining, Xiao Haodong, Zhao Peiquan, Yang Zhenglin

Abstract excerpt

Purpose: This study aimed to investigate the impact of 21 NDP mutations located at the dimer interface, focusing on their potential effects on protein assembly, secretion efficiency, and activation of the Norrin/β-catenin signaling pathway. Methods: The expression level, secretion efficiency, and protein assembly of mutations were analyzed using Western blot. The Norrin/β-catenin signaling pathway activation...

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Source

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Identifiers

PMID: 38517429
DOI: 10.1167/iovs.65.3.31
PMCID: PMC10981164

Genes

FZD4
NDP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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