Differential Gene Expression in<i>Ndph</i>-Knockout Mice in Retinal Development

Abstract excerpt

PURPOSE: Mutations in the NDP gene impair angiogenesis in the eyes of patients diagnosed with a type of blindness belonging to the group of exudative vitreoretinopathies. This study was conducted to investigate the differential gene expression caused by the absence of Norrin (the NDP protein) in the developing mouse retina and to elucidate early pathogenic events. METHODS: A comparative gene expression analysis...

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