Article

SIRT1 mediates KU70 to maintain Genomic Stability in Spermatogonial Stem Cells via NHEJ Repair pathway

2025-10-15

Abstract excerpt

<title>Abstract</title> <p>Background Male infertility is closely related to DNA double-strand breaks in spermatogonial stem cells (SSCs); however, the precise mechanism still remains to be fully elucidated. While SIRT1 is a key regulator of DNA damage response and cellular senescence in other contexts, its role in SSCs is still poorly understood. Methods Single-cell RNA sequencing (scRNA-seq) datasets from human...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8210a9cf-34e6-59a5-af21-468f187a9e20
DOI: 10.21203/rs.3.rs-7799196/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SIRT1 mediates KU70 to maintain Genomic Stability in Spermatogonial Stem Cells via NHEJ Repair pathwayDOI 10.21203/rs.3.rs-7799196/v1Read

Single-cell RNA sequencing reveals transcriptomic landscape and potential targets for human testicular ageingSemantic proximity Read

Transcriptomic and epigenomic profiling of young and aged spermatogonial stem cells reveals molecular targets regulating differentiationSemantic proximity Read

SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizerSemantic proximity Read

OGG1 protects mouse spermatogonial stem cells from reactive oxygen species in culture†.Semantic proximity Read

High Temperature Inhibits The Differentiation of Spermatogonial Stem CellsSemantic proximity Read

SIRT1 Enhances the Survival of Human Embryonic Stem Cells by Promoting DNA RepairSemantic proximity Read

Protecting the heritable genome: DNA damage response mechanisms in spermatogonial stem cellsSemantic proximity Read

KU70 Inhibition Impairs Both Non-Homologous End Joining and Homologous Recombination DNA Damage Repair Through SHP-1 Induced Dephosphorylation of SIRT1 in Adult T-Cell Leukemia-Lymphoma CellsSemantic proximity Read

Ku70 and non-homologous end joining protect testicular cells from DNA damageSemantic proximity Read

Distinctive molecular features of regenerative stem cells in the damaged male germlineSemantic proximity Read

SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPASemantic proximity Read

Association of hMSH5 C85T polymorphism with radiation sensitivity of testicular cell lines GC-1, GC-2, TM3, and TM4.Semantic proximity Read