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Distinctive molecular features of regenerative stem cells in the damaged male germline

6 May 2022

Abstract excerpt

Maintenance of male fertility requires spermatogonial stem cells (SSCs) that self-renew and generate differentiating germ cells for production of spermatozoa. Germline cells are sensitive to genotoxic drugs and patients receiving chemotherapy can become infertile. SSCs surviving treatment mediate germline recovery but pathways driving SSC regenerative responses remain poorly understood. Using models of...

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PMID: 35523793
DOI: 10.1038/s41467-022-30130-z

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