Article

Targeting Ras signaling excitability in cancer cells through combined inhibition of FAK and PI3K

2023-06-13

Abstract excerpt

The Ras/PI3K/ERK signaling network is frequently mutated in various human cancers including cervical cancer and pancreatic cancer. Previous studies showed that the Ras/PI3K/ERK signaling network displays features of excitable systems including propagation of activity waves, all-or-none responses, and refractoriness. Oncogenic mutations lead to enhanced excitability of the network. A positive feedback loop between...

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Literature Corpus work: 81ebdc2b-e07a-593a-8e5d-1f1a53fdd2a4
DOI: 10.1101/2023.06.12.544386

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