Article

A novel protocol for the efficient generation of all three major hippocampal neuronal sub-populations from human pluripotent stem cells

2026-01-23

Abstract excerpt

The diverse computational functions of the human hippocampus rely on coordinated interactions among dentate gyrus (DG), CA3, and CA1 subfields, yet generating all three neuronal identities in vitro - particularly CA1 - has remained challenging. Here we establish a reproducible and modular differentiation protocol that directs human pluripotent stem cells (hPSCs) through dorsomedial telencephalic progenitors to yie...

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Literature Corpus work: 0a5b1317-6abd-57ed-9458-b20e36eb7870
DOI: 10.64898/2026.01.21.700748

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