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Article

Sleep spindle alterations as a novel biomarker for phenotypic stratification in sporadic amyotrophic lateral sclerosis.

Sleep medicine - 1 Aug 2026

Li Min, Han Meiqi, Li Xin, Yu Ning, Zhang Xinyi, Zhao Luqi, Liu Qi, Liu Hu, Wu Jianping, Han Zhongwen, Dong Hui, Liu Yaling

Abstract excerpt

OBJECTIVE: To quantitatively evaluate sleep spindle alterations in sporadic amyotrophic lateral sclerosis (ALS) and explore their potential as biomarkers for diagnosis and phenotypic stratification. METHODS: In this cross-sectional study, overnight sleep electroencephalography was recorded in 97 sporadic ALS patients and 73 matched healthy controls. Sleep spindle parameters (amplitude, duration, density,...

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PMID: 41996956
DOI: 10.1016/j.sleep.2026.108961

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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