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Article

Nutrient-dependent growth defects and mutability of mutators in Escherichia coli.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Jan 2015

Ishizawa Yuuka, Ying Bei-Wen, Tsuru Saburo, Yomo Tetsuya

Abstract excerpt

So-called mutators emerge when mismatch repair and proofreading mechanisms are defective. Mutators not only accelerate the accumulation of mutations that are beneficial for adaptation but also cause a large number of deleterious mutations that are disadvantageous for cell growth. However, such growth defects may be compensated by nutrient availability. How the growth burden is associated with high mutability in...

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PMID: 25378049
DOI: 10.1111/gtc.12199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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