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Calcium binding protein Ncs1 is calcineurin-regulated in <i>Cryptococcus neoformans</i> and essential for cell division and virulence

2020-07-25

Abstract excerpt

Intracellular calcium (Ca 2+ ) is crucial for signal transduction in Cryptococcus neoformans , the major cause of fatal fungal meningitis. The calcineurin pathway is the only Ca 2+ -requiring signalling cascade implicated in cryptococcal stress adaptation and virulence, with Ca 2+ -binding mediated by the EF-hand domains of the Ca 2+ sensor protein calmodulin. In this study, we identified the cryptococcal ort...

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Literature Corpus work
81bf5465-9b1d-57d2-93ea-9b5335e98c88
DOI
10.1101/2020.07.23.218974
Open publication

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