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Hypoxia-inducible factor and cellular senescence in pulmonary aging and disease

26 Feb 2025

Abstract excerpt

Cellular senescence and hypoxia-inducible factor (HIF) signaling are crucial in pulmonary aging and age-related lung diseases such as chronic obstructive pulmonary disease idiopathic pulmonary fibrosis and lung cancer. HIF plays a pivotal role in cellular adaptation to hypoxia, regulating processes like angiogenesis, metabolism, and inflammation. Meanwhile, cellular senescence leads to irreversible cell cycle...

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PMID: 40011266
DOI: 10.1007/s10522-025-10208-z

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