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Epithelial damage and ageing: the perfect storm

27 May 2025

Abstract excerpt

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive disease of lung parenchymal scarring that is triggered by repeated microinjury to a vulnerable alveolar epithelium. It is increasingly recognised that cellular ageing, whether physiological or accelerated due to telomere dysfunction, renders the epithelium less able to cope with injury and triggers changes in epithelial behaviour that ultimately...

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PMID: 40425299
DOI: 10.1136/thorax-2024-222060

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