Article

Rdh10-mediated Retinoic Acid Signaling Regulates the Neural Crest Cell Microenvironment During ENS Formation

2025-01-23

Abstract excerpt

The enteric nervous system (ENS) is formed from vagal neural crest cells (NCC), which generate most of the neurons and glia that regulate gastrointestinal function. Defects in the migration or differentiation of NCC in the gut can result in gastrointestinal disorders such as Hirschsprung disease (HSCR). Although mutations in many genes have been associated with the etiology of HSCR, a significant proportion of aff...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 81ba8593-d516-5ae9-b0ba-9c5359665bd4
DOI: 10.1101/2025.01.23.634504

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rdh10-mediated Retinoic Acid Signaling Regulates the Neural Crest Cell Microenvironment During ENS FormationDOI 10.1101/2025.01.23.634504Read

Retinaldehyde dehydrogenase enzymes regulate colon enteric nervous system structure and function.Semantic proximity Read

Retinoic Acid Accelerates the Specification of Enteric Neural Progenitors from In-Vitro-Derived Neural CrestSemantic proximity Read

The developmental etiology and pathogenesis of Hirschsprung disease.Semantic proximity Read

Retinoic acid accelerates the specification of enteric neural progenitors from <i>in vitro</i> -derived neural crestSemantic proximity Read

Gene- and tissue-level interactions in normal gastrointestinal development and Hirschsprung diseaseSemantic proximity Read

The zebrafish retinol dehydrogenase, rdh1l, is essential for intestinal development and is regulated by the tumor suppressor adenomatous polyposis coli.Semantic proximity Read

The gastrointestinal development ‘parts list’: transcript profiling of embryonic gut development in wildtype and <i>Ret</i> -deficient miceSemantic proximity Read

Rdh10 loss-of-function and perturbed retinoid signaling underlies the etiology of choanal atresia.Semantic proximity Read

Enteric nervous system development: migration, differentiation, and diseaseSemantic proximity Read

Mouse models of Hirschsprung disease and other developmental disorders of the enteric nervous system: Old and new playersSemantic proximity Read

Adenomatous polyposis coli control of retinoic acid biosynthesis is critical for zebrafish intestinal development and differentiation.Semantic proximity Read

Literature review: enteric nervous system development, genetic and epigenetic regulation in the etiology of Hirschsprung's diseaseSemantic proximity Read