Kideraspa: designing variants of staphylococcal protein a based on a diffusion model with kidera factors.

Abstract excerpt

The interaction between staphylococcal protein A (SpA) and human immunoglobulin G (IgG) is pivotal in treating diseases such as cancer, inflammation, infections, and autoimmune disorders. However, acquiring natural SpA variants is labor-intensive, traditional protein design methods often depend on extensive datasets and detailed structural information, limiting their efficiency and applicability. To overcome...

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