Article

Brain corticogenesis and cholesterol homeostasis promotes SARS-CoV-2 infection and replication

2023-02-10

Abstract excerpt

<title>Abstract</title> <p>Although the neuroinvasiveness of SARS-CoV-2 has been extensively studied, the correlation between virus infectivity and brain maturation remained unclear. Here, using human-induced pluripotent stem cells-derived three-dimensional cerebral organoids (CBOs), we present the first quantitative data for long-term kinetics of SARS-CoV-2 propagation in brain for 20 days post-infection. We sho...

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Literature Corpus work: 8195902f-e507-5f87-95f5-80c399d611b6
DOI: 10.21203/rs.3.rs-2481841/v1

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