Article

SARS-CoV-2 Neurotropism and Single Cell Responses in Brain Organoids Containing Innately Developing Microglia

2021-08-06

Abstract excerpt

<title>Abstract</title> <p>Neuropsychiatric manifestations are common in both acute and post-acute phase of SARS-CoV-2 infection, but the mechanism of these effects is unknown. Here, we derive human brain organoids with innately developing microglia to investigate the cellular responses to SARS-CoV-2 infection on a single cell level. We find evidence of limited tropism to SARS-CoV-2 and observe extensive neuronal...

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Literature Corpus work: d2ebed5f-8ca8-5625-bb08-bda1a16c41c5
DOI: 10.21203/rs.3.rs-724318/v1

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