Article

Divergent responses to SARS-CoV-2 infection reveal brain resilience-associated astrocyte programs in centenarians

2026-08-12

Abstract excerpt

<title>Abstract</title> <p>Astrocytes were generated from PBMC-derived iPSCs of centenarians (≥100 years) who recovered from asymptomatic to moderate COVID-19 and from adults (<45 years) who experienced critical disease. Cells were infected with either the ancestral Wuhan SARS-CoV-2 or the more virulent Gamma (P.1) variant and analyzed 48 hours post-infection. Despite comparable infection rates across groups, ast...

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Literature Corpus work: adca82bd-5fa8-5b5a-a81f-fd016b9f1d77
DOI: 10.21203/rs.3.rs-10391383/v1

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