Article

Dihydroceramide desaturase promotes the formation of intraluminal vesicles and inhibits autophagy to increase exosome production

2020-11-10

Abstract excerpt

<h4>Summary</h4> Exosomes are important for cell-cell communication. Deficiencies in the human dihydroceramide desaturase gene, DEGS1 , increase the dihydroceramide-to-ceramide ratio and causes hypomyelinating leukodystrophy. However, the disease mechanism remains unknown. Here, we developed an in vivo assay with spatially controlled expression of exosome markers in Drosophila eye imaginal discs and showed tha...

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Literature Corpus work: 817161d0-79ad-5479-8b5a-c1530c7519a7
DOI: 10.1101/2020.11.10.376046

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