Article

Adaptive immunity to human coronaviruses is widespread but low in magnitude

2021-01-26

Abstract excerpt

Endemic human coronaviruses (hCoV) circulate worldwide but cause minimal mortality. Although seroconversion to hCoV is near ubiquitous during childhood, little is known about hCoV-specific T cell memory in adults. We quantified CD4 T cell and antibody responses to hCoV spike antigens in 42 SARS-CoV-2 uninfected individuals. T cell responses were widespread within conventional memory and cTFH compartments but did n...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 81550a20-7711-5705-ba94-f4e638f1cc19
DOI: 10.1101/2021.01.24.21250074

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Adaptive immunity to human coronaviruses is widespread but low in magnitudeDOI 10.1101/2021.01.24.21250074Read

Functional SARS-CoV-2 cross-reactive CD4 + T cells established in early childhood decline with ageSemantic proximity Read

SARS-CoV-2 reactive T cells in uninfected individuals are likely expanded by beta-coronavirusesSemantic proximity Read

Humoral immunity to endemic coronaviruses in older adults increases post-COVID-19 vaccination and in correlation with their anti-SARS-CoV-2 responsesSemantic proximity Read

The prospect of universal coronavirus immunity: a characterization of reciprocal and non-reciprocal T cell responses against SARS-CoV2 and common human coronavirusesSemantic proximity Read

COVID-19 Infection Induces Substantial Memory B Cell Maturation to Non-Neutralizing Viral TargetsSemantic proximity Read

Differential Adaptive Immune Responses Following SARS-CoV-2 Infection in Children Compared to AdultsSemantic proximity Read

Antibody Responses In Non-Severe SARS-CoV-2 Infections Are Driven By CD4+ T cells and AgeSemantic proximity Read

Post-pandemic memory T cell response to SARS-CoV-2 is durable, broadly targeted, and cross-reactive to the hypermutated BA.2.86 variantSemantic proximity Read

Broadly recognized, cross-reactive SARS-CoV-2 CD4 T cell epitopes are highly conserved across human coronaviruses and presented by common HLA alleles.Semantic proximity Read

S protein-reactive IgG and memory B cell production after human SARS-CoV-2 infection includes broad reactivity to the S2 subunitSemantic proximity Read

SARS-CoV-2–specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigensSemantic proximity Read

High Frequencies of PD-1 <sup>+</sup> TIM3 <sup>+</sup> TIGIT <sup>+</sup> CTLA4 <sup>+</sup> Functionally Exhausted SARS-CoV-2-Specific CD4 <sup>+</sup> and CD8 <sup>+</sup> T Cells Associated with Severe Disease in Critically ill COVID-19 PatientsSemantic proximity Read