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Article

Broadly recognized, cross-reactive SARS-CoV-2 CD4 T cell epitopes are highly conserved across human coronaviruses and presented by common HLA alleles.

Cell reports - 14 Jun 2022

Becerra-Artiles Aniuska, Calvo-Calle J Mauricio, Co Mary Dawn, Nanaware Padma P, Cruz John, Weaver Grant C, Lu Liying, Forconi Catherine, Finberg Robert W, Moormann Ann M, Stern Lawrence J

Abstract excerpt

Sequence homology between SARS-CoV-2 and common-cold human coronaviruses (HCoVs) raises the possibility that memory responses to prior HCoV infection can affect T cell response in COVID-19. We studied T cell responses to SARS-CoV-2 and HCoVs in convalescent COVID-19 donors and identified a highly conserved SARS-CoV-2 sequence, S811-831, with overlapping epitopes presented by common MHC class II proteins HLA-DQ5...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35675811
DOI: 10.1016/j.celrep.2022.110952
PMCID: PMC9135679

Genes

CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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