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Functional SARS-CoV-2 cross-reactive CD4 + T cells established in early childhood decline with age

14 Mar 2023

Abstract excerpt

Pre-existing SARS-CoV-2-reactive T cells have been identified in SARS-CoV-2-unexposed individuals, potentially modulating COVID-19 and vaccination outcomes. Here, we provide evidence that functional cross-reactive memory CD4 + T cell immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is established in early childhood, mirroring early seroconversion with seasonal human coronavirus OC43....

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PMID: 36917669
DOI: 10.1073/pnas.2220320120

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