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High Frequencies of PD-1 + TIM3 + TIGIT + CTLA4 + Functionally Exhausted SARS-CoV-2-Specific CD4 + and CD8 + T Cells Associated with Severe Disease in Critically ill COVID-19 Patients

2022-01-31

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<h4>ABSTRACT</h4> SARS-CoV-2-specific memory T cells that cross-react with common cold coronaviruses (CCCs) are present in both healthy donors and COVID-19 patients. However, whether these cross-reactive T cells play a role in COVID-19 pathogenesis versus protection remain to be fully elucidated. In this study, we characterized cross-reactive SARS-CoV-2-specific CD4 + and CD8 + T cells, targeting genome-wide co...

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Literature Corpus work: 2a8187e5-c34d-543f-ac0f-39165fdfd693
DOI: 10.1101/2022.01.30.478343

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High Frequencies of PD-1 + TIM3 + TIGIT + CTLA4 + Functionally Exhausted SARS-CoV-2-Specific CD4 + and CD8 + T Cells Associated with Severe Disease in Critically ill COVID-19 PatientsDOI 10.1101/2022.01.30.478343Read

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High Frequencies of PD-1 <sup>+</sup> TIM3 <sup>+</sup> TIGIT <sup>+</sup> CTLA4 <sup>+</sup> Functionally Exhausted SARS-CoV-2-Specific CD4 <sup>+</sup> and CD8 <sup>+</sup> T Cells Associated with Severe Disease in Critically ill COVID-19 Patients

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