Article

Early screening of colorectal cancer using feature engineering with artificial intelligence-enhanced analysis of nanoscale chromatin modifications

2023-10-31

Abstract excerpt

Colonoscopy is accurate but inefficient for colorectal cancer (CRC) prevention due to the low (~ 7–8%) prevalence of target lesions, advanced adenomas. We leveraged rectal mucosa to identify patients who harbor CRC field carcinogenesis by evaluating chromatin 3D architecture. Supranucleosomal disordered chromatin chains (~ 5–20 nm, ~ 1 kbp) fold into chromatin packing domains (~ 100–200 nm, ~ 100–1,000 kbp). In tu...

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Literature Corpus work: 813fbad0-b067-51d1-b355-48d052219395
DOI: 10.21203/rs.3.rs-3500134/v1

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