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Article

Tissue Elasticity as a Diagnostic Marker of Molecular Mutations in Morphologically Heterogeneous Colorectal Cancer.

International journal of molecular sciences - 14 May 2024

Plekhanov Anton A, Kozlov Dmitry S, Shepeleva Anastasia A, Kiseleva Elena B, Shimolina Liubov E, Druzhkova Irina N, Plekhanova Maria A, Karabut Maria M, Gubarkova Ekaterina V, Gavrina Alena I, Krylov Dmitry P, Sovetsky Alexander A, Gamayunov Sergey V, Kuznetsova Daria S, Zaitsev Vladimir Y, Sirotkina Marina A, Gladkova Natalia D

Abstract excerpt

The presence of molecular mutations in colorectal cancer (CRC) is a decisive factor in selecting the most effective first-line therapy. However, molecular analysis is routinely performed only in a limited number of patients with remote metastases. We propose to use tissue stiffness as a marker of the presence of molecular mutations in CRC samples. For this purpose, we applied compression optical coherence...

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Identifiers

PMID: 38791375
DOI: 10.3390/ijms25105337
PMCID: PMC11120711

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