Spectral biomarkers for chemoprevention of colonic neoplasia: a placebo-controlled double-blinded trial with aspirin.

doi:10.1136/gutjnl-2015-309996

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Article

Spectral biomarkers for chemoprevention of colonic neoplasia: a placebo-controlled double-blinded trial with aspirin.

Gut - 1 Feb 2017

Roy Hemant K, Turzhitsky Vladimir, Wali Ramesh, Radosevich Andrew J, Jovanovic Borko, Della'Zanna Gary, Umar Asad, Rubin David T, Goldberg Michael J, Bianchi Laura, De La Cruz Mart, Bogojevic Andrej, Helenowski Irene B, Rodriguez Luz, Chatterton Robert, Skripkauskas Silvia, Page Katherine, Weber Christopher R, Huang Xiaoke, Richmond Ellen, Bergan Raymond C, Backman Vadim

Abstract excerpt

OBJECTIVE: A major impediment to translating chemoprevention to clinical practice has been lack of intermediate biomarkers. We previously reported that rectal interrogation with low-coherence enhanced backscattering spectroscopy (LEBS) detected microarchitectural manifestations of field carcinogenesis. We now wanted to ascertain if reversion of two LEBS markers spectral slope (SPEC) and fractal dimension (FRAC)...

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Identifiers

PMID: 26503631
DOI: 10.1136/gutjnl-2015-309996
PMCID: PMC5108693

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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