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Nanoscale changes in chromatin organization represent the initial steps of tumorigenesis: a transmission electron microscopy study

14 Mar 2014

Abstract excerpt

BACKGROUND: Nuclear alterations are a well-known manifestation of cancer. However, little is known about the early, microscopically-undetectable stages of malignant transformation. Based on the phenomenon of field cancerization, the tissue in the field of a tumor can be used to identify and study the initiating events of carcinogenesis. Morphological changes in nuclear organization have been implicated in the...

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PMID: 24629088
DOI: 10.1186/1471-2407-14-189

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