CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis.

doi:10.1158/0008-5472.CAN-20-3651

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Article

CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis.

Cancer research - 15 Aug 2021

Laine Anni, Nagelli Srikar G, Farrington Caroline, Butt Umar, Cvrljevic Anna N, Vainonen Julia P, Feringa Femke M, Grönroos Tove J, Gautam Prson, Khan Sofia, Sihto Harri, Qiao Xi, Pavic Karolina, Connolly Denise C, Kronqvist Pauliina, Elo Laura L, Maurer Jochen, Wennerberg Krister, Medema Rene H, Joensuu Heikki, Peuhu Emilia, de Visser Karin, Narla Goutham, Westermarck Jukka

Abstract excerpt

Basal-like breast cancers (BLBC) are characterized by defects in homologous recombination (HR), deficient mitotic checkpoint, and high-proliferation activity. Here, we discover CIP2A as a candidate driver of BLBC. CIP2A was essential for DNA damage-induced initiation of mouse BLBC-like mammary tumors and for survival of HR-defective BLBC cells. CIP2A was dispensable for normal mammary gland development and for...

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PMID: 34145035
DOI: 10.1158/0008-5472.CAN-20-3651
PMCID: PMC8373817

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CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis.PMID 34145035Read ↗

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