Article

An explainable model of host genetic interactions linked to COVID-19 severity

2022-01-11

Abstract excerpt

<title>Abstract</title> <p> We employed a multifaceted computational strategy to identify the genetic factors contributing to increased risk of severe COVID-19 infection from a Whole Exome Sequencing (WES) dataset of a cohort of 2000 Italian patients. We coupled a stratified <italic>k</italic> -fold screening, to rank variants more associated with severity, with training of multiple supervised classifiers, to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 811bce3f-dbdf-5b5e-babf-98101159da31
DOI: 10.21203/rs.3.rs-1062190/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An explainable model of host genetic interactions linked to COVID-19 severityDOI 10.21203/rs.3.rs-1062190/v2Read

An explainable model of host genetic interactions linked to COVID-19 severity.Semantic proximity Read

An Explainable Host Genetic Severity Predictor Model for COVID-19 PatientsSemantic proximity Read

Computational Network Analysis of Host Genetic Risk Variants of Severe COVID-19Semantic proximity Read

Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severitySemantic proximity Read

Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.Semantic proximity Read

A Unique Patient Stratification Method Combined with a Machine Learning Approach Identifies Novel Genetic Susceptibility and Protective Factors for Severe COVID-19 in a Hungarian Population.Semantic proximity Read

A second update on mapping the human genetic architecture of COVID-19Semantic proximity Read

A second update on mapping the human genetic architecture of COVID-19Semantic proximity Read

Multi-Layered Genomic and Clinical Analysis Identifies Novel Variants, Co-Occurring Single Nucleotide Polymorphism Pairs, and Clinical Determinants of Host-Pathogen Interaction in COVID-19 Severity.Semantic proximity Read

Post-Mendelian Genetic Model in COVID-19Semantic proximity Read

Host genetic factors determining COVID-19 susceptibility and severity.Semantic proximity Read

Genetic Analysis and Predictive Modeling of COVID-19 Severity in a Hospital-Based Patient Cohort.Semantic proximity Read