Article
An explainable model of host genetic interactions linked to COVID-19 severity.
Communications biology - 26 Oct 2022
Onoja Anthony, Picchiotti Nicola, Fallerini Chiara, Baldassarri Margherita, Fava Francesca, Colombo Francesca, Chiaromonte Francesca, Renieri Alessandra, Furini Simone, Raimondi Francesco
Abstract excerpt
We employed a multifaceted computational strategy to identify the genetic factors contributing to increased risk of severe COVID-19 infection from a Whole Exome Sequencing (WES) dataset of a cohort of 2000 Italian patients. We coupled a stratified k-fold screening, to rank variants more associated with severity, with the training of multiple supervised classifiers, to predict severity based on screened features....
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