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Genetic Analysis and Predictive Modeling of COVID-19 Severity in a Hospital-Based Patient Cohort.

Biomolecules - 10 Mar 2025

Alloza-Moral Iraide, Aldekoa-Etxabe Ane, Tulloch-Navarro Raquel, Fiat-Arriola Ainhoa, Mar Carmen, Urrechaga Eloisa, Ponga Cristina, Artiga-Folch Isabel, Garcia-Bediaga Naiara, Aspichueta Patricia, Martin Cesar, Zarandona-Garai Aitor, Pérez-Fernández Silvia, Arana-Arri Eunate, Triviño Juan-Carlos, Uranga Ane, España Pedro-Pablo, Vandenbroeck-van-Caeckenbergh Koen

Abstract excerpt

The COVID-19 pandemic has had a devastating impact, with more than 7 million deaths worldwide. Advanced age and comorbidities partially explain severe cases of the disease, but genetic factors also play a significant role. Genome-wide association studies (GWASs) have been instrumental in identifying loci associated with SARS-CoV-2 infection. Here, we report the results from a >820 K variant GWAS in a COVID-19...

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Identifiers

PMID: 40149929
DOI: 10.3390/biom15030393
PMCID: PMC11940120

Genes

DMBT1
HTRA1
KIF19

Provenance

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