Article

Single-Cell Atlas of Patient-Derived Trophoblast Organoids in Ongoing Pregnancies

2022-10-02

Abstract excerpt

Trophoblast organoids (TOs) hold great promise for elucidating human placental development and function. By deriving TOs in ongoing pregnancies using chorionic villus sampling (CVS), we established a platform to study trophoblast differentiation and function in early pregnancy, including pregnancies with different fetal genetic abnormalities. We addressed cellular heterogeneity of CVS-derived TOs by providing a si...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9f7a1a4a-1c3d-5471-b342-e3ca3399e968
DOI: 10.3390/organoids1020009

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-Cell Atlas of Patient-Derived Trophoblast Organoids in Ongoing PregnanciesDOI 10.3390/organoids1020009Read

Single-cell assessment of trophoblast stem cell-based organoids as human placenta-modeling platformsSemantic proximity Read

A unified developmental framework of the human placenta in its uterine environment in vivo and in vitroSemantic proximity Read

Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placentaSemantic proximity Read

Single-cell transcriptomics reveal differences between chorionic and basal plate cytotrophoblasts and trophoblast stem cellsSemantic proximity Read

A Multiomics, Spatiotemporal, and Single Cell Atlas for Mapping Cell-Type-Specific Dysregulation at the Maternal-Fetal InterfaceSemantic proximity Read

Advancing Human Placental Modeling Through Stem-Cell-Derived Trophoblast Organoids and Reprogramming InnovationsSemantic proximity Read

Spatial multiomics map of trophoblast development in early pregnancySemantic proximity Read

Human Placental Endothelial Cell and Trophoblast Heterogeneity and Differentiation Revealed by Single-Cell RNA SequencingSemantic proximity Read

Generating Functional Multicellular Organoids from Human Placenta VilliSemantic proximity Read

Trophoblast Organoids: Capturing the Complexity of Early Placental Development In VitroSemantic proximity Read

Comparative analysis of rhesus macaque and human placental organoids highlights evolutionary differences in placentationSemantic proximity Read

Regionally distinct trophoblast regulate barrier function and invasion in the human placentaSemantic proximity Read