Article

Protein-bound molybdenum cofactor is bioavailable and rescues molybdenum cofactor-deficient <i>C. elegans</i>

2020-10-08

Abstract excerpt

The molybdenum cofactor (Moco) is a 520 dalton prosthetic group that is synthesized in all domains of life. In animals, four oxidases (among them sulfite oxidase) use Moco as a prosthetic group. Moco is essential in animals; humans with mutations in genes that encode Moco-biosynthetic enzymes display lethal neurological and developmental defects. Moco supplementation seems a logical therapy, however the instabilit...

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Literature Corpus work: 80ffb68f-84d4-59f3-9097-63e8fe6a692a
DOI: 10.1101/2020.10.08.332338

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