Article

Identification of novel anti-bacterial compounds from a chemically highly diverse pathways-based library using phenotypic screens in amoebae host models

2018-12-17

Abstract excerpt

Legionella pneumophila and tubercular Mycobacteria are the causative agents of potentially fatal diseases due to their pathogenesis but also to the emergence of antibiotic resistance that limits treatment strategies. The aim of our study is to explore the antimicrobial activity of a small ligand-based chemical library of 1,255 structurally diverse compounds. These compounds were screened in a combination of three...

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Identifiers and source

Literature Corpus work: 80f7f223-6163-5335-bdcc-4eb0af24f036
DOI: 10.1101/497032

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