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Dysregulation of transposable elements and PIWI-interacting RNAs in myelodysplastic neoplasms

23 Jan 2025

Abstract excerpt

BACKGROUND: Myelodysplastic neoplasms (MDS) are heterogeneous hematopoietic disorders characterized by ineffective hematopoiesis and genome instability. Mobilization of transposable elements (TEs) is an important source of genome instability leading to oncogenesis, whereas small PIWI-interacting RNAs (piRNAs) act as cellular suppressors of TEs. However, the roles of TEs and piRNAs in MDS remain unclear. METHODS:...

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PMID: 39849644
DOI: 10.1186/s40364-025-00725-x

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