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Epigenetics in Neurodegenerative Diseases: The Role of Histone Deacetylases

5 Oct 2018

Abstract excerpt

BACKGROUND & OBJECTIVE: Imbalance in histone acetylation levels and consequently the dysfunction in transcription are associated with a wide variety of neurodegenerative diseases. Histone proteins acetylation and deacetylation is carried out by two opposite acting enzymes, histone acetyltransferases and histone deacetylases (HDACs), respectively. In-vitro and in-vivo animal models of neurodegenerative diseases...

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Amyotrophic Lateral Sclerosis Research
Epigenetics and DNA Methylation
Histone Deacetylase Inhibitors Research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30289079
DOI: 10.2174/1871527317666181004155136

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