Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetics in Neurodegenerative Diseases: The Role of Histone Deacetylases

5 Oct 2018

Abstract excerpt

BACKGROUND & OBJECTIVE: Imbalance in histone acetylation levels and consequently the dysfunction in transcription are associated with a wide variety of neurodegenerative diseases. Histone proteins acetylation and deacetylation is carried out by two opposite acting enzymes, histone acetyltransferases and histone deacetylases (HDACs), respectively. In-vitro and in-vivo animal models of neurodegenerative diseases...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to Epigenetics and DNA Methylation
Share to Histone Deacetylase Inhibitors Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30289079
DOI: 10.2174/1871527317666181004155136

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetics in Neurodegenerative Diseases: The Role of Histone DeacetylasesPMID 30289079Read ↗

Histone Deacetylase Inhibitors: A Therapeutic Key in Neurological Disorders?Semantic proximity Read ↗

Understanding the Role of Histone Deacetylase and their Inhibitors in Neurodegenerative Disorders: Current Targets and Future PerspectiveSemantic proximity Read ↗

Histone Deacetylase Inhibition in Alzheimer’s Disease: Molecular Mechanisms, Therapeutic Potential, and Future PerspectivesSemantic proximity Read ↗

HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?Semantic proximity Read ↗

HDACs in the Brain: From Chromatin Remodeling to Neurodegenerative DiseaseSemantic proximity Read ↗

HDAC4 as a potential therapeutic target in neurodegenerative diseases: a summary of recent achievementsSemantic proximity Read ↗

Targeting HDACs: A Promising Therapy for Alzheimer's DiseaseSemantic proximity Read ↗

Histone deacetylases as targets for the treatment of human neurodegenerative diseasesSemantic proximity Read ↗

Multiple roles of HDAC inhibition in neurodegenerative conditionsSemantic proximity Read ↗

The potential of epigenetic therapies in neurodegenerative diseasesSemantic proximity Read ↗

Molecular targets of histone deacetylase inhibitors in neurodegeneration and neuroprotectionSemantic proximity Read ↗

Targeting Histone Deacetylases: A Novel Approach in Parkinson’s DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.