Article

Mitochondrial function determines severity but not risk of amyotrophic lateral sclerosis

2022-06-01

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. Selective vulnerability of energy-intensive motor neurons (MNs) has fostered speculation that mitochondrial function is a determinant of ALS. Previously, the position of mitochondrial function in the pathogenic cascade leading to neurotoxicity has been unclear. We separated upstream genetic determinants of mitochondrial function, including g...

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Literature Corpus work: 8096f9d0-0273-5b13-ba78-be287d11a610
DOI: 10.1101/2022.05.31.494229

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