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Article

Distinct UNC13A Haplotype Blocks Define Disease Severity and Survival in Chinese Amyotrophic Lateral Sclerosis.

European journal of neurology - 1 Jun 2026

He Cailin, Liu Ziqin, Yuan Yanchun, Tang Linxin, Wang Meirong, Li Yongchao, Zhao Qianqian, Weng Ling, Du Juan, Wu Hanjun, Hu Fan, Xu Renshi, Guo Jifeng, Shen Lu, Tang Beisha, Wang Junling

Abstract excerpt

BACKGROUND: UNC13A is a genetic modifier of amyotrophic lateral sclerosis (ALS) in European populations, but its role in Chinese patients remains incompletely characterized. We investigated the spectrum of UNC13A variation and its impact on disease risk and progression in a Chinese ALS cohort. METHODS: We performed an integrated genetic analysis of 1,533 Chinese ALS patients and 1,405 controls, including rare...

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Identifiers

PMID: 42223334
DOI: 10.1111/ene.70653
PMCID: PMC13239109

Genes

UNC13A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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