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Article

Genetic contributions to mitochondrial dysfunction in amyotrophic lateral sclerosis etiology.

HGG advances - 9 Jul 2026

Russell Nikki D, Downie Jonathan M, Bromberg Mark B, Pulst Stefan M, Jorde Lynn B

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with multiple genetic causes. Given the strong evidence of mitochondrial dysfunction in ALS, this study aimed to identify genetic contributors to ALS by focusing on genes involved in mitochondrial function. Whole-genome and whole-exome sequencing data from 1,034 individuals with ALS were analyzed using two distinct computational tools, which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41966055
DOI: 10.1016/j.xhgg.2026.100614
PMCID: PMC13147394

Genes

POLG
SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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