Article

Regulatory T cells clonally expand and contribute to stromal cell function in fibrotic response to synthetic implants

2026-01-06

Abstract excerpt

Fibrosis plays a key role in both chronic disease progression and failure of synthetic biomaterial implants. However, the contribution of adaptive immunity to fibrotic development remains incompletely understood, particularly for regulatory T cells (Tregs). Here, we used single-cell multiomic profiling, integrating transcriptomics with T cell receptor (TCR) sequencing, to map Treg heterogeneity and clonal dynamics...

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Literature Corpus work: 809094f8-657f-54d0-9131-d70195c19fc4
DOI: 10.64898/2026.01.05.697727

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