Article

BBSome-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue

2024-01-25

Abstract excerpt

The primary cilium has emerged as critical in regulating whole-body energy metabolism, as reflected in the Bardet-Biedl syndrome (BBS), where primary cilia dysfunction leads to obesity due to hyperphagia and white adipose tissue (WAT) remodeling. The regulation of cell fate and differentiation of adipocyte precursor cells (APCs) is key to maintaining WAT homeostasis during obesity. Using mice that recapitulated th...

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Literature Corpus work: 357d8597-a3f8-5165-b572-eea22ebea888
DOI: 10.1101/2024.01.25.576526

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