Article

A Minimal Biophysical Model of Neocortical Pyramidal Cells: Implications for Frontal Cortex Microcircuitry and Field Potential Generation

2020-01-30

Abstract excerpt

Ca 2+ spikes initiated in the apical dendrites of layer-5 pyramidal cells (PC) underlie nonlinear dynamic changes in the gain of cellular response, which is critical for top-down cognitive control. Detailed models with several compartments and dozens of ionic channels have been proposed to account for this Ca 2+ spike-dependent gain with its associated critical frequency. However, current models do not account f...

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Literature Corpus work: a574137e-d23c-5d5c-808c-8d9b8dd8a265
DOI: 10.1101/2020.01.29.925180

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