Article

Probing Action Potential Generation and Timing under Multiplexed Basal Dendritic Computations Using Two-photon 3D Holographic Uncaging

2022-09-27

Abstract excerpt

<h4>SUMMARY</h4> Basal dendrites of layer 5 cortical pyramidal neurons exhibit Na + and NMDAR spikes, and are uniquely poised to influence somatic output. Nevertheless, due to technical limitations, how multibranch basal dendritic integration shapes action-potential output remains poorly mapped. Here, we combine 3D two-photon holographic transmitter-uncaging, whole-cell dynamic-clamp, and biophysical modeling, t...

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Literature Corpus work: b3126d63-8cc4-5fee-b3e5-75ebd0ca15a2
DOI: 10.1101/2022.09.26.509562

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