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N-Cadherin Dynamically Regulates Schwannoma Migration and Represents a Novel Therapeutic Target in NF2-Related Schwannomatosis

2026-02-19

Abstract excerpt

<title>Abstract</title> <p>NF2-related schwannomatosis (NF2-SWN) is a devastating tumor predisposition syndrome marked by multiple schwannomas and substantial morbidity. Vestibular Schwannoma (VS), the hallmark tumor, causes deafness, vertigo and potentially fatal brainstem compression. A subset develops brainstem adhesions, making surgery - the only treatment option – highly risky in the absence of FDA-approved...

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Literature Corpus work
800c4362-b78d-5ce5-af48-254fa5d23e38
DOI
10.21203/rs.3.rs-8817797/v1
Open publication

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