Article

Monensin as potential drug for treatment of SLeX-positive tumors

2024-03-13

Abstract excerpt

Colorectal (CRC) and gastric (GC) cancers remain the top lethal cancers and targeted therapies in this setting are still very limited. Sialyl Lewis X (SLeX), a cancer-associated glycan highly expressed in both CRC and GC, plays a crucial role in cancer cell dissemination and metastasis. Thus, presenting a promising but still underexplored therapeutic target. In this work, we performed a high-throughput screening (...

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Literature Corpus work: 7ff47084-74fd-5f06-9e2d-ac021ed696de
DOI: 10.1101/2024.03.11.24304048

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