Article
High Diversity of Glycosphingolipid Glycans of Colorectal Cancer Cell Lines Reflects the Cellular Differentiation Phenotype.
Molecular & cellular proteomics : MCP - 1 Jun 2022
Wang Di, Madunić Katarina, Zhang Tao, Mayboroda Oleg A, Lageveen-Kammeijer Guinevere S M, Wuhrer Manfred
Abstract excerpt
Colorectal cancer (CRC)-associated changes of protein glycosylation have been widely studied. In contrast, the expression of glycosphingolipid (GSL) patterns in CRC has, hitherto, remained largely unexplored. Even though GSLs are major carriers of cell surface carbohydrates, they are understudied due to their complexity and analytical challenges. In this study, we provide an in-depth analysis of GSL glycans of 22...
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